Nanocoatings onto Arteries via Layer-by-Layer Deposition:  Toward the in Vivo Repair of Damaged Blood Vessels

• Published in: Journal of the American Chemical Society 2003-06, Vol.125 (25), p.7494-7495
• Main Authors: Thierry, Benjamin, Winnik, Françoise M, Merhi, Yahye, Tabrizian, Maryam
• Format: Article
• Language: English
• Subjects: Animals; Arginine - administration & dosage; Arginine - therapeutic use; Biological and medical sciences; Chitin - analogs & derivatives; Chitin - metabolism; Chitin - therapeutic use; Chitosan; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Fundamental and applied biological sciences. Psychology; Hyaluronic Acid - metabolism; Hyaluronic Acid - therapeutic use; Microscopy, Confocal; Molecular and cellular biology; Nanotechnology - methods; Platelet Adhesiveness - drug effects; Swine; Vascular Diseases - drug therapy
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja034321x

The deposition of polysaccharide-based self-assembled nanocoatings onto damaged arteries is described as a means not only to protect a damaged artery against thrombogenesis, but also to control the healing processes by incorporating biologically active components within the multilayer. As shown by confocal microscopy, the polysaccharide multilayer was retained on the artery in physiological condition and prevented platelet adhesion. Diffusion of the polysaccharides within the artery was also observed and may be used to efficiently target the vascular wall. The NO-precursor l-arginine was used a drug model and incorporated within the self-assembled layers.