Food Intake during the Normal Activity Phase Prevents Obesity and Circadian Desynchrony in a Rat Model of Night Work

Shift work or night work is associated with hypertension, metabolic syndrome, cancer, and other diseases. The cause for these pathologies is proposed to be the dissociation between the temporal signals from the biological clock and the sleep/activity schedule of the night worker. We investigated the...

Full description

Saved in:
Bibliographic Details
Published in:Endocrinology (Philadelphia) 2010-03, Vol.151 (3), p.1019-1029
Main Authors: Salgado-Delgado, Roberto, Angeles-Castellanos, Manuel, Saderi, Nadia, Buijs, Ruud M, Escobar, Carolina
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - physiology
Biological activity
Biological and medical sciences
Biological clocks
Body Temperature
Body Weight
Chronobiology
Circadian Rhythm
Circadian rhythms
Corticosterone - blood
Disease Models, Animal
Eating
Food intake
Fundamental and applied biological sciences. Psychology
Hypertension
Intra-Abdominal Fat - metabolism
Male
Medical sciences
Metabolic diseases
Metabolic disorders
Metabolic syndrome
Night
Nighttime
Obesity
Obesity - prevention & control
Phase shift
Rats
Rats, Wistar
Schedules
Shift work
Suprachiasmatic Nucleus - physiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Work Schedule Tolerance - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Shift work or night work is associated with hypertension, metabolic syndrome, cancer, and other diseases. The cause for these pathologies is proposed to be the dissociation between the temporal signals from the biological clock and the sleep/activity schedule of the night worker. We investigated the mechanisms promoting metabolic desynchrony in a model for night work in rats, based on daily 8-h activity schedules during the resting phase. We demonstrate that the major alterations leading to internal desynchrony induced by this working protocol, flattened glucose and locomotor rhythms and the development of abdominal obesity, were caused by food intake during the rest phase. Shifting food intake to the normal activity phase prevented body weight increase and reverted metabolic and rhythmic disturbances of the shift work animals to control ranges. These observations demonstrate that feeding habits may prevent or induce internal desynchrony and obesity. Rats voluntarily ingest food while working in their normal resting phase, resulting in obesity and internal desynchrony; this is prevented by shifting food to the activity phase.
ISSN:0013-7227
1945-7170
DOI:10.1210/en.2009-0864