Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues

PDMS-based microfluidic devices combined with lanthanide-based immunocomplexes have been successfully tested for the multiplex detection of biomarkers on cancerous tissues, revealing an enhanced sensitivity compared to classical organic dyes.

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Bibliographic Details
Published in:Analyst (London) 2009-10, Vol.134 (10), p.1991-1993
Main Authors: BO SONG, SIVAGNANAM, Venkataragavalu, VANDEVYVER, Caroline D. B, HEMMILÄ, Ilkka, LEHR, Hans-Anton, GIJS, Martin A. M, BÜNZLI, Jean-Claude G
Format: Article
Language:English
Subjects:
Analytical chemistry
Biomarkers, Tumor - analysis
Biomarkers, Tumor - immunology
Cell Line, Tumor
Chemistry
Dimethylpolysiloxanes - chemistry
Exact sciences and technology
Humans
Immunoassay
Lab-On-A-Chip Devices
Lanthanoid Series Elements - chemistry
Luminescent Measurements
Neoplasms - pathology
Spectrometric and optical methods
Time Factors
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Description
Summary:PDMS-based microfluidic devices combined with lanthanide-based immunocomplexes have been successfully tested for the multiplex detection of biomarkers on cancerous tissues, revealing an enhanced sensitivity compared to classical organic dyes.
ISSN:0003-2654
1364-5528
DOI:10.1039/b911301k