A Real-Time, Telemetric Method for Continuous Measurement of Portal Pressures

The ability to longitudinally monitor portal and splanchnic pressures would greatly enhance the understanding of acute and chronic liver disease by helping to assess the immediate and long-term impact of therapeutic manipulations. However, a technique for measuring portal pressures in the ambulatory...

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Bibliographic Details
Published in:The Journal of surgical research 2010-04, Vol.159 (2), p.618-621
Main Authors: Schwartz, Jason, M.D, Rohrwasser, Andreas, Ph.D, Hillas, Elaine, B.S, Hatch, Jenny, M.S, Sorensen, John, M.D, Gayowski, Timothy, M.D, Hutson, William, M.D, Lalouel, Jean-Marc, D.Sc
Format: Article
Language:English
Subjects:
Acute Disease
animal
Animals
Biological and medical sciences
Chronic Disease
cirrhosis
Disease Models, Animal
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Infusion Pumps, Implantable
Liver Diseases - physiopathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Mice
Mice, Inbred C57BL
Other diseases. Semiology
portal hypertension
Portal Pressure - physiology
Splanchnic Circulation - physiology
spleen
Surgery
telemetry
Telemetry - instrumentation
Telemetry - methods
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Description
Summary:The ability to longitudinally monitor portal and splanchnic pressures would greatly enhance the understanding of acute and chronic liver disease by helping to assess the immediate and long-term impact of therapeutic manipulations. However, a technique for measuring portal pressures in the ambulatory setting is not currently available. To overcome this difficulty, we utilized an approach that involved the implantation of a miniature telemetric device, equipped with a specially-designed pressure transmission catheter, into the spleen of an anesthetized mouse. Using this approach, portal pressures were measured continuously over 5 d in conscious, unrestrained animals, the availability of which will help facilitate studies of the portal circulation requiring long-term stability.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2009.10.026