Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease

Renal dysfunction commonly occurs in multiple myeloma (MM) and is caused by deposition of abnormal light chain within various compartments of the kidney. Renal pathologic findings are diverse and include cast nephropathy (CN), amyloidosis and light-chain deposition disease (LCDD). We report a case o...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2010-04, Vol.25 (4), p.1340-1343
Main Authors: Lorenz, Elizabeth C., Sethi, Sanjeev, Poshusta, Tanya L., Ramirez-Alvarado, Marina, Kumar, Shaji, Lager, Donna J., Fervenza, Fernando C., Leung, Nelson
Format: Article
Language:English
Subjects:
Adult
amyloidosis
Amyloidosis - complications
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Emergency and intensive care: renal failure. Dialysis management
Female
Humans
Hypergammaglobulinemia - complications
Immunoglobulin Light Chains
Intensive care medicine
Kidney Diseases - complications
light chain
Medical sciences
Multiple Myeloma - complications
myeloma
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
nephropathy
Renal failure
Renal Insufficiency - etiology
Renal Insufficiency - therapy
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Summary:Renal dysfunction commonly occurs in multiple myeloma (MM) and is caused by deposition of abnormal light chain within various compartments of the kidney. Renal pathologic findings are diverse and include cast nephropathy (CN), amyloidosis and light-chain deposition disease (LCDD). We report a case of renal failure in a patient with MM caused by concurrent CN, amyloidosis and LCDD which has not been previously described.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfp735