Nafronyl ion-selective membrane electrodes and their use in pharmaceutical analysis

A simple potentiometric method is described for the rapid determination of nafronyl-drugs in pharmaceutical preparations such as tablets. Nafronyl ion-selective membrane electrodes with either the nafronyl-dipicrylamine ion-pair complex in 1,2-dichloroethane or the nafronyl-dinonylnaphthalenesulphon...

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Bibliographic Details
Published in:Talanta (Oxford) 1986, Vol.33 (1), p.101-103
Main Authors: Ionescu, Mariana S., Badea, Veronica, Baiulescu, G.E., Coşofreţ, V.V.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Summary:A simple potentiometric method is described for the rapid determination of nafronyl-drugs in pharmaceutical preparations such as tablets. Nafronyl ion-selective membrane electrodes with either the nafronyl-dipicrylamine ion-pair complex in 1,2-dichloroethane or the nafronyl-dinonylnaphthalenesulphonic acid ion-pair complex in a PVC matrix as electroactive materials were used. Both electrodes exhibit near-Nernstian responses to protonated-nafronyl activity from 10 −2 to about 10 −5 M, in pH ranges that depend on the nature of the electroactive material used in the membrane. Nafronyl in the mg-range can be determined by potentiometric titration with sodium tetraphenylborate solution, with a relative standard deviation of less than 2.0%. No interference from any excipients in the tablets was observed.
ISSN:0039-9140
1873-3573
DOI:10.1016/0039-9140(86)80021-2