Spectrophotometric methods for the determination of tolnaftate

Two simple and sensitive visible spectrophotometric methods (methods A and B) for the determination of tolnaftate in bulk samples and formulations are described. Method A (λ max 490 nm) involves the reaction of tolnaftate with 2,6-dichloroquinone-4-chlorimide (DCQC: Gibb's reagent), while metho...

Full description

Saved in:
Bibliographic Details
Published in:Talanta (Oxford) 1993-04, Vol.40 (4), p.571-576
Main Authors: Sastry, C.S.P., Sastry, B.S., Rao, J.Venkateswara, Krishna, R.Rama
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two simple and sensitive visible spectrophotometric methods (methods A and B) for the determination of tolnaftate in bulk samples and formulations are described. Method A (λ max 490 nm) involves the reaction of tolnaftate with 2,6-dichloroquinone-4-chlorimide (DCQC: Gibb's reagent), while method B (λ max 530 nm) is based on a similar reaction of the drug with p- N, N-dimethylphenylene diamine in the presence of chloramine-T. Both these methods are applicable to pure samples as well as formulations of the drug.
ISSN:0039-9140
1873-3573
DOI:10.1016/0039-9140(93)80019-N