Electrochemical studies of rutin interacting with hemoglobin and determination of hemoglobin

Electrochemical investigation of the interaction of rutin (Rt) with hemoglobin (Hb) at a glassy carbon electrode is reported for the first time. With the addition of hemoglobin in a rutin solution, both the reduction and oxidation currents decrease with few changes in the peak potentials. The reacti...

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Bibliographic Details
Published in:Talanta (Oxford) 2001-05, Vol.54 (4), p.591-596
Main Authors: Bao, Xiaoyu, Zhu, Zhiwei, Li, Nan-Qiang, Chen, Jianguo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cyclic voltammetry
General pharmacology
Hemoglobin
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rutin
Supramolecule
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Summary:Electrochemical investigation of the interaction of rutin (Rt) with hemoglobin (Hb) at a glassy carbon electrode is reported for the first time. With the addition of hemoglobin in a rutin solution, both the reduction and oxidation currents decrease with few changes in the peak potentials. The reaction of rutin with hemoglobin forms a nonelectroactive supramolecular complex Hb–Rt. The equilibrium constant for complex is calculated to be 3.4×10 6. A satisfactory result has been obtained for the determination of hemoglobin in clinical blood samples.
ISSN:0039-9140
1873-3573
DOI:10.1016/S0039-9140(00)00667-6