Differential derivative spectrophotometric determination of phenobarbitone and phenytoin sodium in combined tablet preparations

A pH-induced differential derivative spectrophotometric procedure has been developed for the simultaneous determination of Phenobarbitone (PBT) and Phenytoin sodium (DPH Na) in tablet preparations. The method comprized of measurement of difference absorptivities derivatized in second order ( ΔD 2) o...

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Bibliographic Details
Published in:Talanta (Oxford) 1997-05, Vol.44 (5), p.917-922
Main Authors: Prasad, C.V.N., Gautam, A., Bharadwaj, V., Parimoo, P.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Phenobarbitone
Phenytoin sodium
Spectrophotometric
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Summary:A pH-induced differential derivative spectrophotometric procedure has been developed for the simultaneous determination of Phenobarbitone (PBT) and Phenytoin sodium (DPH Na) in tablet preparations. The method comprized of measurement of difference absorptivities derivatized in second order ( ΔD 2) of a tablet extract in 0.01 N NaOH relative to that of an equimolar solution in 0.01 N HCl at wavelengths of 244.8 and 252.8 nm respectively. The presence of identical zero-crossing points for pure drug and tablet extract solutions established the non-interference of the excipients in the absorption at these wavelengths. The compliance of Beer's law was adhered over a concentration range of 7.5–25 μg ml −1 for both PBT and DPH.
ISSN:0039-9140
1873-3573
DOI:10.1016/S0039-9140(96)02139-X