Voltammetric studies of the effect of Cisplatin-liposome on Hela cells

In this paper, the voltammetric method was used for the first time to study the effect of Cisplatin-liposome on Hela cells. The results showed the voltammetric behavior of Hela cells was irreversible and the peak current had linear relationship with the cell number. With both Cisplatin-liposome conc...

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Bibliographic Details
Published in:Talanta (Oxford) 2001-10, Vol.55 (4), p.693-698
Main Authors: Ci, Yun-xiang, Zhai, Qi, Wang, Shan, Chang, Wen-bao, Zhang, Chun-yang, Ma, Hui, Chen, Die-yan, Zhao, Min-zheng, Hu, Sheng-wen
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Cisplatin-liposome
General pharmacology
Hela cells
Medical sciences
Pharmacology. Drug treatments
Voltammetry
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Summary:In this paper, the voltammetric method was used for the first time to study the effect of Cisplatin-liposome on Hela cells. The results showed the voltammetric behavior of Hela cells was irreversible and the peak current had linear relationship with the cell number. With both Cisplatin-liposome concentration and treating time increasing, the peak current decreased. The peak current decreasing was in accordance with the nuclear damage and loss of mitochondrial membrane potential revealed by two-photon laser scanning microscopy and confocal laser scanning microscopy. This voltammetric method may provide a simple way to study the electron-transfer mechanism in drug-treating cells.
ISSN:0039-9140
1873-3573
DOI:10.1016/S0039-9140(01)00480-5