Determination of diphenhydramine by capillary electrophoresis with tris(2,2′-bipyridyl)ruthenium(II) electrochemiluminescence detection

Tris(2,2′-bipyridyl)ruthenium(II) electrochemiluminescence detection in a capillary electrophoresis separation system was used for the determination of diphenhydramine. In this study, platinum disk electrode (300 μm in diameter) was used as a working electrode and the influence of applied potential...

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Published in:Talanta (Oxford) 2003-03, Vol.59 (3), p.453-459
Main Authors: Liu, Jifeng, Cao, Weidong, Yang, Xiurong, Wang, Erkang
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Capillary electrophoresis
Diphenhydramine
Electrochemiluminescence detection
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Rabbit plasma
Rabbit urine
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Cao, Weidong
Yang, Xiurong
Wang, Erkang
description Tris(2,2′-bipyridyl)ruthenium(II) electrochemiluminescence detection in a capillary electrophoresis separation system was used for the determination of diphenhydramine. In this study, platinum disk electrode (300 μm in diameter) was used as a working electrode and the influence of applied potential and buffer conditions were investigated. Under optimal conditions: 1.2 V applied potential, pH 8.50, 15 kV separation voltage and 10 mmol l −1 running buffer, the calibration curve of diphenhydramine was linear over the range of 4×10 −8 to 1×10 −5 mol l −1. This technique gave satisfactory precision, and relative standard deviations of migration times and chemiluminescence peak intensities were less than 1 and 6%, respectively. The technique was applied to animal studies for determination of diphenhydramine extracted from rabbit plasma and urine samples, and the extraction efficiency were between 92 and 98.5%.
doi_str_mv 10.1016/S0039-9140(02)00535-0
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The technique was applied to animal studies for determination of diphenhydramine extracted from rabbit plasma and urine samples, and the extraction efficiency were between 92 and 98.5%.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Capillary electrophoresis</subject><subject>Diphenhydramine</subject><subject>Electrochemiluminescence detection</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. 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subjects Analysis
Biological and medical sciences
Capillary electrophoresis
Diphenhydramine
Electrochemiluminescence detection
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Rabbit plasma
Rabbit urine
title Determination of diphenhydramine by capillary electrophoresis with tris(2,2′-bipyridyl)ruthenium(II) electrochemiluminescence detection
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