Bromometric determination of carbimazole

Direct bromometric titration of carbimazole using N-bromosuccinimide (NBS) in the presence of methyl red as indicator and three indirect titrations using NBS, potassium bromate and dibromohydantoin (DBH) are developed. The direct procedure can be adopted for quantities of carbimazole ranging from 2–...

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Bibliographic Details
Published in:Talanta (Oxford) 1993-04, Vol.40 (4), p.577-583
Main Authors: El-Bardicy, M.G., El-Saharty, Y.S., Tawakkol, M.S.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Summary:Direct bromometric titration of carbimazole using N-bromosuccinimide (NBS) in the presence of methyl red as indicator and three indirect titrations using NBS, potassium bromate and dibromohydantoin (DBH) are developed. The direct procedure can be adopted for quantities of carbimazole ranging from 2–12 mg with mean accuracies of 100.2 ± 0.5. The indirect procedures can be used for quantities of the drug ranging from 1–6 mg using NBS and DBH and 2–16 mg using potassium bromate with mean accuracies of 100.11 ± 0.3, 100.49 ± 0.31 and 100.26 ± 0.51 respectively. The proposed procedures have been successfully applied for the analysis of the drug in tablet form and their validity has been checked using the standard addition technique. The reaction products were separated by TLC methods and their structure was elucidated using IR and NMR spectroscopy. The stoichiometry and the possible pathways of the reaction were postulated and presented.
ISSN:0039-9140
1873-3573
DOI:10.1016/0039-9140(93)80020-R