Myofibroblastoma of the larynx: A study of two cases

• Published in: Head & neck 2003-07, Vol.25 (7), p.606-611
• Main Authors: MacGregor, Allison R., Batsakis, John G., El‐Naggar, Adel K.
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics; Humans; Laryngeal Neoplasms - pathology; Laryngeal Neoplasms - surgery; larynx; Male; Medical sciences; mesenchymal tumors; myofibroblast; myofibroblastoma; Neoplasms, Muscle Tissue - pathology; Neoplasms, Muscle Tissue - surgery; Otorhinolaryngology. Stomatology; spindle cell tumor; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the upper aerodigestive tract; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.10272

Background. We describe, for the first time, the occurrence of two pure examples of spindle cell neoplasm with fibrous and smooth muscle differentiation in the larynx. Materials and Method. Tissue sections from both tumors stained with hematoxylin and eosin were reviewed. Immunophenotypic analysis using keratin, S‐100 protein, SMA, and h‐Caldesmon markers was performed. Results. Tumors were seen as raised submucosal nodules in the glottic region of two elderly male patients. Histopathologically, the lesions were unencapsulated and composed of spindle cells that manifested variable cellular anaplasia and expressed SMA and were negative for keratin, S‐100, and h‐Caldesmon. Conclusions. We document histologically low‐grade malignant myofibroblastic tumors of the larynx. Complete excision is advised. © 2003 Wiley Periodicals, Inc. Head Neck 25: 606–611, 2003