The facile and efficient synthesis of 8-chloroadenosine 3',5'-cyclic monophosphate by phosphorylative cyclization of 8-chloroadenosine and its characterization by(1)H and (13)C NMR spectroscopy

Purine nucleosides were chlorinated by the reaction of acyl chloride in DMF with MCPBA under mild conditions with moderate yields. And, satisfactory method for the synthesis of ribonucleoside-3',5'-cyclic phosphates and its characterization by(1)H and(13)C nmr spectroscopy is described.

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Bibliographic Details
Published in:Archives of pharmacal research 1997-04, Vol.20 (2), p.176-179
Main Authors: Woo, N T, Jin, S Y, Cho, D J, Kim, N S, Bae, E H, Jung, J H, Ham, W H, Jung, Y H
Format: Article
Language:English
Online Access:Get full text
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Description
Summary:Purine nucleosides were chlorinated by the reaction of acyl chloride in DMF with MCPBA under mild conditions with moderate yields. And, satisfactory method for the synthesis of ribonucleoside-3',5'-cyclic phosphates and its characterization by(1)H and(13)C nmr spectroscopy is described.
ISSN:0253-6269
DOI:10.1007/BF02974006