Synthesis and antitumor activity of 3-arylisoquinoline derivatives

In order to study the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylen-edioxy-2-vinylphenyl)isoquinoline-1 (2H)-one (2), which has exhibited significant antitumor activity, chemical modifications of2 were performed to yield the corresponding products (3-7). Further systemati...

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Bibliographic Details
Published in:Archives of pharmacal research 1997-06, Vol.20 (3), p.264-268
Main Authors: Cho, W J, Yoo, S J, Park, M J, Chung, B H, Lee, C O
Format: Article
Language:English
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Summary:In order to study the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylen-edioxy-2-vinylphenyl)isoquinoline-1 (2H)-one (2), which has exhibited significant antitumor activity, chemical modifications of2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds (9a-9g), which were tested forin vitro antitumor activity against five different human cancer cell lines.
ISSN:0253-6269
1976-3786
DOI:10.1007/bf02976155