Changes of nitric oxide synthase activity and free methylarginines contents in regenerating rat liver after partial hepatectomy

In the present study, liver regeneration rate (%) was increased up to 70% 3 days after partial hepatectomy (PH). Nitric oxide synthase (NOS) activity in liver tissue as well as serum nitrite/nitrate content had no timed response, revealing no significant difference between shamoperated and partially...

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Published in:Archives of pharmacal research 1997-06, Vol.20 (3), p.239-246
Main Authors: Lee, Y J, Nam, S W, Seo, D W, Ahn, S H, Ko, Y K, Sung, D S, Han, J W, Hong, S Y, Lee, H W
Format: Article
Language:English
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Summary:In the present study, liver regeneration rate (%) was increased up to 70% 3 days after partial hepatectomy (PH). Nitric oxide synthase (NOS) activity in liver tissue as well as serum nitrite/nitrate content had no timed response, revealing no significant difference between shamoperated and partially hepatectomized rat liver. Contents of free methylarginines in liver tissue were increased biphasically in a time-dependent manner after PH. However, those in serum did not exhibit the same patterns as in liver. Taken together, the results suggest that N(G)-monomethyl-L-arginine (MMA) and N(G), N(G)-dimethylarginine (DMA) play a role in inhibiting nitric oxide (NO) synthesis in regenerating rat liver because the increase of their contents was synchronized with NOS expression.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02976151