Acquired Factor VIII and von Willebrand Factor (aFVIII/VWF) Deficiency and Hypothyroidism in a Case With Hypopituitarism

This article reports a female who presented with bleeding, acquired factor VIII and von Willebrand factor (aFVIII-VWF) deficiency, and central deficiency in the thyroid and adrenal axis (Sheehan’s syndrome). After starting hormone replacement therapy, relief of bleeding manifestations was associated...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2010-02, Vol.16 (1), p.107-109
Main Authors: Oliveira, Miriam C., Kramer, Caroline K., Marroni, Caroline P., Leães, Carolina G.S., Viana, Luciana, Roithman, Sérgio, Schmaedecke, Alexandre, Pereira-Lima, Júlia F.S.
Format: Article
Language:English
Subjects:
Adult
Factor VIII - metabolism
Female
Health risk assessment
Hemophilia A - etiology
Hemorrhage - blood
Hemorrhage - etiology
Hormone replacement therapy
Humans
Hypothyroidism
Hypothyroidism - blood
Hypothyroidism - complications
von Willebrand Diseases - etiology
von Willebrand Factor - metabolism
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Summary:This article reports a female who presented with bleeding, acquired factor VIII and von Willebrand factor (aFVIII-VWF) deficiency, and central deficiency in the thyroid and adrenal axis (Sheehan’s syndrome). After starting hormone replacement therapy, relief of bleeding manifestations was associated with correction of both FVIII and VWF to normal. This report draws attention to a rare association between the acquired form of von Willebrand disease and hypothyroidism of central origin.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029608319948