Evaluation of a 5-year Programme to Prevent Mother-to-child Transmission of HIV Infection in Northern Uganda

Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 2010-02, Vol.56 (1), p.43-52
Main Authors: Ahoua, Laurence, Ayikoru, Harriet, Gnauck, Katherine, Odaru, Grace, Odar, Emmanuel, Ondoa–Onama, Christine, Pinoges, Loretxu, Balkan, Suna, Olson, David, Pujades-Rodríguez, Mar
Format: Article
Language:English
Subjects:
Adult
Anti-HIV Agents - therapeutic use
Biological and medical sciences
Counseling
Female
General aspects
HIV Infections - drug therapy
HIV Infections - prevention & control
HIV Infections - transmission
HIV-1
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious Disease Transmission, Vertical - prevention & control
Infectious Disease Transmission, Vertical - statistics & numerical data
Infectious diseases
Kaplan-Meier Estimate
Male
Medical sciences
Middle Aged
Mothers
Postnatal Care - utilization
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Pregnancy Complications, Infectious - epidemiology
Prenatal Care
Retrospective Studies
Rural Population
Treatment Outcome
Uganda - epidemiology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Young Adult
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Summary:Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19 017 women, 1 037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother–infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07–3.36) and of weaning age
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/fmp054