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Evaluation of a 5-year Programme to Prevent Mother-to-child Transmission of HIV Infection in Northern Uganda
Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out...
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| Published in: | Journal of tropical pediatrics (1980) 2010-02, Vol.56 (1), p.43-52 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 52 |
| container_issue | 1 |
| container_start_page | 43 |
| container_title | Journal of tropical pediatrics (1980) |
| container_volume | 56 |
| creator | Ahoua, Laurence Ayikoru, Harriet Gnauck, Katherine Odaru, Grace Odar, Emmanuel Ondoa–Onama, Christine Pinoges, Loretxu Balkan, Suna Olson, David Pujades-Rodríguez, Mar |
| description | Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19 017 women, 1 037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother–infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07–3.36) and of weaning age |
| doi_str_mv | 10.1093/tropej/fmp054 |
| format | article |
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We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19 017 women, 1 037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother–infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07–3.36) and of weaning age <6 months (OR 2.55, 95% CI 1.42–4.58), and lower in infants with diagnosed acute illness (OR 0.30, 95% CI 0.16–0.55). Mother-to-child HIV cumulative transmission rate was 8.3%, and 15.5% when HIV-related deaths were considered. Improved tracking of HIV-exposed infants is needed in PMTCT programmes where access to early infant diagnosis is still limited.</description><identifier>ISSN: 0142-6338</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/fmp054</identifier><identifier>PMID: 19602489</identifier><identifier>CODEN: JTRPAO</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Anti-HIV Agents - therapeutic use ; Biological and medical sciences ; Counseling ; Female ; General aspects ; HIV Infections - drug therapy ; HIV Infections - prevention & control ; HIV Infections - transmission ; HIV-1 ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious Disease Transmission, Vertical - prevention & control ; Infectious Disease Transmission, Vertical - statistics & numerical data ; Infectious diseases ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Middle Aged ; Mothers ; Postnatal Care - utilization ; Pregnancy ; Pregnancy Complications, Infectious - drug therapy ; Pregnancy Complications, Infectious - epidemiology ; Prenatal Care ; Retrospective Studies ; Rural Population ; Treatment Outcome ; Uganda - epidemiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Young Adult</subject><ispartof>Journal of tropical pediatrics (1980), 2010-02, Vol.56 (1), p.43-52</ispartof><rights>The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2009</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-cbe516e235ff9c7ffd65479c0b6f60072d15c338cca9b0006ad31ecd6445d31e3</citedby><cites>FETCH-LOGICAL-c362t-cbe516e235ff9c7ffd65479c0b6f60072d15c338cca9b0006ad31ecd6445d31e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22394448$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19602489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahoua, Laurence</creatorcontrib><creatorcontrib>Ayikoru, Harriet</creatorcontrib><creatorcontrib>Gnauck, Katherine</creatorcontrib><creatorcontrib>Odaru, Grace</creatorcontrib><creatorcontrib>Odar, Emmanuel</creatorcontrib><creatorcontrib>Ondoa–Onama, Christine</creatorcontrib><creatorcontrib>Pinoges, Loretxu</creatorcontrib><creatorcontrib>Balkan, Suna</creatorcontrib><creatorcontrib>Olson, David</creatorcontrib><creatorcontrib>Pujades-Rodríguez, Mar</creatorcontrib><title>Evaluation of a 5-year Programme to Prevent Mother-to-child Transmission of HIV Infection in Northern Uganda</title><title>Journal of tropical pediatrics (1980)</title><addtitle>J Trop Pediatr</addtitle><description>Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19 017 women, 1 037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother–infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07–3.36) and of weaning age <6 months (OR 2.55, 95% CI 1.42–4.58), and lower in infants with diagnosed acute illness (OR 0.30, 95% CI 0.16–0.55). Mother-to-child HIV cumulative transmission rate was 8.3%, and 15.5% when HIV-related deaths were considered. Improved tracking of HIV-exposed infants is needed in PMTCT programmes where access to early infant diagnosis is still limited.</description><subject>Adult</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Counseling</subject><subject>Female</subject><subject>General aspects</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Infections - transmission</subject><subject>HIV-1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious Disease Transmission, Vertical - prevention & control</subject><subject>Infectious Disease Transmission, Vertical - statistics & numerical data</subject><subject>Infectious diseases</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mothers</subject><subject>Postnatal Care - utilization</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - drug therapy</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Prenatal Care</subject><subject>Retrospective Studies</subject><subject>Rural Population</subject><subject>Treatment Outcome</subject><subject>Uganda - epidemiology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious Disease Transmission, Vertical - prevention & control</topic><topic>Infectious Disease Transmission, Vertical - statistics & numerical data</topic><topic>Infectious diseases</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mothers</topic><topic>Postnatal Care - utilization</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - drug therapy</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Prenatal Care</topic><topic>Retrospective Studies</topic><topic>Rural Population</topic><topic>Treatment Outcome</topic><topic>Uganda - epidemiology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahoua, Laurence</creatorcontrib><creatorcontrib>Ayikoru, Harriet</creatorcontrib><creatorcontrib>Gnauck, Katherine</creatorcontrib><creatorcontrib>Odaru, Grace</creatorcontrib><creatorcontrib>Odar, Emmanuel</creatorcontrib><creatorcontrib>Ondoa–Onama, Christine</creatorcontrib><creatorcontrib>Pinoges, Loretxu</creatorcontrib><creatorcontrib>Balkan, Suna</creatorcontrib><creatorcontrib>Olson, David</creatorcontrib><creatorcontrib>Pujades-Rodríguez, Mar</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of tropical pediatrics (1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahoua, Laurence</au><au>Ayikoru, Harriet</au><au>Gnauck, Katherine</au><au>Odaru, Grace</au><au>Odar, Emmanuel</au><au>Ondoa–Onama, Christine</au><au>Pinoges, Loretxu</au><au>Balkan, Suna</au><au>Olson, David</au><au>Pujades-Rodríguez, Mar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of a 5-year Programme to Prevent Mother-to-child Transmission of HIV Infection in Northern Uganda</atitle><jtitle>Journal of tropical pediatrics (1980)</jtitle><addtitle>J Trop Pediatr</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>56</volume><issue>1</issue><spage>43</spage><epage>52</epage><pages>43-52</pages><issn>0142-6338</issn><eissn>1465-3664</eissn><coden>JTRPAO</coden><abstract>Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19 017 women, 1 037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother–infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07–3.36) and of weaning age <6 months (OR 2.55, 95% CI 1.42–4.58), and lower in infants with diagnosed acute illness (OR 0.30, 95% CI 0.16–0.55). Mother-to-child HIV cumulative transmission rate was 8.3%, and 15.5% when HIV-related deaths were considered. Improved tracking of HIV-exposed infants is needed in PMTCT programmes where access to early infant diagnosis is still limited.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>19602489</pmid><doi>10.1093/tropej/fmp054</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0142-6338 |
| ispartof | Journal of tropical pediatrics (1980), 2010-02, Vol.56 (1), p.43-52 |
| issn | 0142-6338 1465-3664 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Adult Anti-HIV Agents - therapeutic use Biological and medical sciences Counseling Female General aspects HIV Infections - drug therapy HIV Infections - prevention & control HIV Infections - transmission HIV-1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious Disease Transmission, Vertical - prevention & control Infectious Disease Transmission, Vertical - statistics & numerical data Infectious diseases Kaplan-Meier Estimate Male Medical sciences Middle Aged Mothers Postnatal Care - utilization Pregnancy Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - epidemiology Prenatal Care Retrospective Studies Rural Population Treatment Outcome Uganda - epidemiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Young Adult |
| title | Evaluation of a 5-year Programme to Prevent Mother-to-child Transmission of HIV Infection in Northern Uganda |
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