Evidence of multiple pyrethroid resistance mechanisms in the malaria vector Anopheles gambiae sensu stricto from Nigeria

Pyrethroid insecticide resistance in Anopheles gambiae sensu stricto is a major concern to malaria vector control programmes. Resistance is mainly due to target-site insensitivity arising from a single point mutation, often referred to as knockdown resistance ( kdr). Metabolic-based resistance mecha...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2009-11, Vol.103 (11), p.1139-1145
Main Authors: Awolola, T.S., Oduola, O.A., Strode, C., Koekemoer, L.L., Brooke, B., Ranson, H.
Format: Article
Language:English
Subjects:
Animals
Anopheles
Anopheles - drug effects
Anopheles - genetics
Anopheles gambiae
Biological and medical sciences
General aspects
Human protozoal diseases
Infectious diseases
Insecticide resistance
Insecticide Resistance - genetics
Insecticides - pharmacology
Larva - drug effects
Larva - genetics
Malaria
Malaria - genetics
Malaria - transmission
Medical sciences
Metabolism
Mosquito Control
Nigeria
Oligonucleotide Array Sequence Analysis
Parasitic diseases
Point Mutation - genetics
Protozoal diseases
Pyrethrins - pharmacology
Pyrethroid
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Summary:Pyrethroid insecticide resistance in Anopheles gambiae sensu stricto is a major concern to malaria vector control programmes. Resistance is mainly due to target-site insensitivity arising from a single point mutation, often referred to as knockdown resistance ( kdr). Metabolic-based resistance mechanisms have also been implicated in pyrethroid resistance in East Africa and are currently being investigated in West Africa. Here we report the co-occurrence of both resistance mechanisms in a population of An. gambiae s.s. from Nigeria. Bioassay, synergist and biochemical analysis carried out on resistant and susceptible strains of An. gambiae s.s. from the same geographical area revealed >50% of the West African kdr mutation in the resistant mosquitoes but
ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2008.08.021