Genome wide scan using homozygosity mapping and linkage analyses of a single pedigree with affective disorder suggests oligogenic inheritance

The present study reports results from a genome scan on a family with bipolar affective disorder in which the parents are first cousins and four of the offsprings and one grandchild have affective disorder. The study searched for risk loci for affective disorder by searching for homozygous segments...

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Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2003-07, Vol.120B (1), p.63-71
Main Authors: Ewald, Henrik, Kruse, Torben A., Mors, Ole
Format: Article
Language:English
Subjects:
affective disorder
autozygosity
Bipolar Disorder - epidemiology
Bipolar Disorder - genetics
Chromosome Mapping - methods
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 21
complex disorder
Consanguinity
Denmark - epidemiology
Genetic Linkage
genome scan
Genome, Human
Genotype
Haplotypes
homozygosity mapping
Homozygote
Humans
Male
Microsatellite Repeats
Mood Disorders - genetics
Pedigree
Phenotype
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Summary:The present study reports results from a genome scan on a family with bipolar affective disorder in which the parents are first cousins and four of the offsprings and one grandchild have affective disorder. The study searched for risk loci for affective disorder by searching for homozygous segments or more complex inherited loci using parametric and non‐parametric multipoint linkage analysis. In addition dominant, multipoint, affecteds‐only linkage analyses were performed as a supplement to previous analyses. On chromosomes 2q31.3, 10, 12q24, and 21q22.3 evidence for a risk locus was obtained by parametric and/or non‐parametric linkage analyses and by haplotype sharing. As other studies have found significant or suggestive linkage to bipolar disorder in these chromosome regions this suggests that an oligogenic mode of inheritance is possible in this family involving at least some of the loci. Finally, the work discusses whether homozygosity mapping using parametric and non‐parametric linkage analyses may be of value for complex diseases including rare subphenotypes of such disorders. © 2003 Wiley‐Liss, Inc.
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.20039