Differences in immunogenicity and vaccine potential of peptides from Schistosoma mansoni glyceraldehyde 3-phosphate dehydrogenase

Six peptides, A, B1, B, C, D and E derived from the primary sequence of Schistosoma mansoni glyceraldehyde 3-phosphate dehydrogenase (SG3PDH) were selected based on lowest homology to human G3PDH and used for immunization of BALB/c mice. Peptides B1 and D induced immunoglobulin (Ig) G1, IgG2a and Ig...

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Bibliographic Details
Published in:Vaccine 2003-07, Vol.21 (23), p.3290-3300
Main Authors: Tallima, Hatem, Montash, Mona, Vepřek, Pavel, Velek, Jiři, Ježek, Jan, El Ridi, Rashika
Format: Article
Language:English
Subjects:
Animals
Antibodies, Helminth - biosynthesis
Antibodies, Helminth - immunology
Antibody Formation - immunology
Antigens, Helminth - immunology
Biological and medical sciences
Blotting, Western
Enzyme-Linked Immunosorbent Assay
Female
Fundamental and applied biological sciences. Psychology
Glyceraldehyde 3-phosphate dehydrogenase
Glyceraldehyde-3-Phosphate Dehydrogenases - chemistry
Glyceraldehyde-3-Phosphate Dehydrogenases - immunology
Immunity, Cellular - immunology
Immunization
Interferon-gamma - biosynthesis
Invertebrates
Mice
Mice, Inbred BALB C
Nemathelminthia. Plathelmintha
Parasite Egg Count
Peptides - chemistry
Peptides - immunology
Schistosoma mansoni
Schistosoma mansoni - enzymology
Schistosoma mansoni - immunology
Schistosomiasis mansoni - parasitology
Schistosomiasis mansoni - prevention & control
Synthetic peptide vaccine
Tropical medicine
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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Summary:Six peptides, A, B1, B, C, D and E derived from the primary sequence of Schistosoma mansoni glyceraldehyde 3-phosphate dehydrogenase (SG3PDH) were selected based on lowest homology to human G3PDH and used for immunization of BALB/c mice. Peptides B1 and D induced immunoglobulin (Ig) G1, IgG2a and IgG2b antibodies that reacted with native and denatured SG3PDH, and were associated with significant ( P
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(03)00180-4