Cadherin expression in the inner ear of developing zebrafish

Cadherins are cell adhesion molecules that have been implicated in development of a variety of organs including the ear. In this study we analyzed expression patterns of three zebrafish cadherins (Cadherin-2, -4, and -11) in the embryonic and larval zebrafish inner ear using both in situ hybridizati...

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Bibliographic Details
Published in:Gene Expression Patterns 2003-06, Vol.3 (3), p.337-339
Main Authors: Novince, Z.M., Azodi, E., Marrs, J.A., Raymond, P.A., Liu, Q.
Format: Article
Language:English
Subjects:
Animals
Cadherins - biosynthesis
Cadherins - genetics
Cell adhesion molecule
Development
Ear, Inner - embryology
Ear, Inner - metabolism
Gene Expression Profiling
Hair cell
In Situ Hybridization
RNA, Messenger - metabolism
Statoacoustic ganglion
Zebrafish
Zebrafish - embryology
Zebrafish - metabolism
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Summary:Cadherins are cell adhesion molecules that have been implicated in development of a variety of organs including the ear. In this study we analyzed expression patterns of three zebrafish cadherins (Cadherin-2, -4, and -11) in the embryonic and larval zebrafish inner ear using both in situ hybridization and immunocytochemical methods. All three Cadherins exhibit distinct spatiotemporal patterns of expression during otic vesicle morphogenesis. Cadherin-2 and Cadherin-4 proteins and their respective mRNAs were detected mainly in the sensory patches and the statoacoustic ganglion (SAg), respectively. In contrast, cadherin-11mRNA was widely expressed earlier in the otic placode, and later became restricted to a subset of cells in the inner ear, including hair cells.
ISSN:1567-133X
1872-7298
DOI:10.1016/S1567-133X(03)00030-9