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Copper-Catalyzed Annulation of 2-Formylazoles with o-Aminoiodoarenes

In the presence of catalytic CuI and sparteine, 2-formylpyrroles can be annulated with o-aminoiodoarenes to give substituted pyrrolo[1,2-a]quinoxalines and related heterocycles. The reaction also works for annulation of 2-formylindoles, 2-formylimidazole, 2-formylbenzimidazole, and a 3-formylpyrazol...

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Bibliographic Details
Published in:Journal of organic chemistry 2010-02, Vol.75 (3), p.992-994
Main Authors: Reeves, Jonathan T, Fandrick, Daniel R, Tan, Zhulin, Song, Jinhua J, Lee, Heewon, Yee, Nathan K, Senanayake, Chris H
Format: Article
Language:English
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Summary:In the presence of catalytic CuI and sparteine, 2-formylpyrroles can be annulated with o-aminoiodoarenes to give substituted pyrrolo[1,2-a]quinoxalines and related heterocycles. The reaction also works for annulation of 2-formylindoles, 2-formylimidazole, 2-formylbenzimidazole, and a 3-formylpyrazole.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo9025644