Anesthesia for Combined Cardiac Surgery and Liver Transplant

• Published in: Journal of cardiothoracic and vascular anesthesia 2010-04, Vol.24 (2), p.285-292
• Main Authors: DeStephano, Christopher C., BS, Harrison, Barry A., MD, Mordecai, Monica, MD, Crawford, Claudia C., MD, Shine, Timothy S.J., MD, Hewitt, Winston R., MD, McBride, Lawrence R., MD, Murray, Michael J., PhD, MD
• Format: Article
• Language: English
• Subjects: Aged; Anesthesia & Perioperative Care; Anesthesia, General - adverse effects; Anesthesia, General - methods; Anesthesia, General - mortality; aortic stenosis; aortic valve replacement; Cardiac Surgical Procedures - adverse effects; Cardiac Surgical Procedures - methods; Cardiac Surgical Procedures - mortality; coronary artery bypass graft; coronary artery disease; Critical Care; end-stage liver disease; Female; Humans; Liver Transplantation - adverse effects; Liver Transplantation - methods; Liver Transplantation - mortality; Male; Middle Aged; orthotopic liver transplant; Preoperative Care - adverse effects; Preoperative Care - methods; Preoperative Care - mortality; Retrospective Studies; Risk Factors
• ISSN: 1053-0770; 1532-8422
• DOI: 10.1053/j.jvca.2009.10.014

Objective To describe aspects of anesthesia for combined cardiac surgery and orthotopic liver transplant (OLT). Design Retrospective case series. Setting Hospital with cardiac surgery and liver transplant programs. Participants Nine patients between September 1998 and July 2006. Intervention Combined cardiac surgery and OLT. Measurement and Main Results Demographic and outcome data were recorded for each patient. Multiple intraoperative parameters were collected at baseline, after induction of anesthesia, after cardiac surgery, and after OLT. Five patients underwent combined OLT and coronary artery bypass graft (CABG) surgery. Four patients underwent combined OLT and aortic valve replacement (AVR) to relieve aortic stenosis. One of these 4 patients also had a saphenous vein graft to the left anterior descending artery. The CABG/OLT patients had hypertension, diabetes, or both, and multiple coronary arteries were affected although ejection fraction was preserved. The 1 death in this group was unrelated to a coronary event. The AVR/OLT patients had aortic stenosis that met American Heart Association guidelines for AVR. One death, within 24 hours of surgery, was associated with severe pulmonary artery hypertension. The median transfusion volumes were 12 units of packed red blood cells, 22 units of fresh frozen plasma, and 30 units of platelets. Three of the 9 patients required renal replacement therapy postoperatively. The median duration of intubation was 2 days, and length of stay in the intensive care unit was 5.5 days. Conclusion Combined cardiac and OLT surgery is complex and serious morbidity occurs, but successful outcomes are attainable.