Preparation of MPEG–PLA nanoparticle for honokiol delivery in vitro

Honokiol (HK) shows potential application in cancer treatment, but its poor water solubility restricts clinical application greatly. In this paper, monomethoxy poly(ethylene glycol)–poly(lactic acid) (MPEG–PLA) was synthesized by ring-opening polymerization and processed into nanoparticle for honoki...

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Bibliographic Details
Published in:International journal of pharmaceutics 2010-02, Vol.386 (1), p.262-267
Main Authors: Zheng, XiuLing, Kan, Bing, Gou, MaLing, Fu, ShaoZhi, Zhang, Juan, Men, Ke, Chen, LiJuan, Luo, Feng, Zhao, YingLan, Zhao, Xia, Wei, YuQuan, Qian, ZhiYong
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Biological and medical sciences
Biphenyl Compounds - chemistry
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Chemistry, Pharmaceutical
Chromatography, Gel
Dose-Response Relationship, Drug
Drug Carriers
Female
General pharmacology
Hemolysis - drug effects
Honokiol
Humans
Kinetics
Lignans - chemistry
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Molecular Weight
MPEG–PLA
Nanoparticles
Nanotechnology
Ovarian Neoplasms - pathology
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyesters - chemistry
Polyesters - toxicity
Polyethylene Glycols - chemistry
Polyethylene Glycols - toxicity
Solubility
Solvent extract method
Solvents - chemistry
Surface Properties
Technology, Pharmaceutical - methods
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Description
Summary:Honokiol (HK) shows potential application in cancer treatment, but its poor water solubility restricts clinical application greatly. In this paper, monomethoxy poly(ethylene glycol)–poly(lactic acid) (MPEG–PLA) was synthesized by ring-opening polymerization and processed into nanoparticle for honokiol delivery. Chemical structure of the synthesized polymer was confirmed by 1H NMR, and its molecular weight was determined by gel permeation chromatography (GPC). Honokiol loaded MPEG–PLA nanoparticles were prepared by solvent extract method. And particle size distribution, morphology, drug loading, drug release profile and anticancer activity in vitro were studied in detail. The described honokiol loaded MPEG–PLA nanoparticles in this paper might be a novel formulation for honokiol delivery.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2009.11.014