Nonsteroidal Anti-inflammatory Drugs in Ophthalmology

Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are increasingly employed in ophthalmology to reduce miosis and inflammation, manage scleritis, and prevent and treat cystoid macular edema associated with cataract surgery. In addition, they may decrease postoperative pain and photophobia assoc...

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Bibliographic Details
Published in:Survey of ophthalmology 2010-03, Vol.55 (2), p.108-133
Main Authors: Kim, Stephen J., MD, Flach, Allan J., MD, Jampol, Lee M., MD
Format: Article
Language:English
Subjects:
age-related macular degeneration
allergic conjunctivitis
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biological and medical sciences
cataract surgery
cyclooxygenase inhibitors
cystoid macular edema
Diabetes. Impaired glucose tolerance
diabetic retinopathy
Drug Approval
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Eye Diseases - drug therapy
Eye Diseases - etiology
Eye Diseases - metabolism
Humans
Lens diseases
Medical sciences
Miscellaneous
mydriasis
nonsteroidal anti-inflammatory drugs
NSAIDs
Ophthalmic Solutions - administration & dosage
Ophthalmic Solutions - pharmacokinetics
Ophthalmic Solutions - pharmacology
Ophthalmology
Ophthalmology - methods
postoperative inflammation
prostaglandins
Retinopathies
United States
United States Food and Drug Administration
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Summary:Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are increasingly employed in ophthalmology to reduce miosis and inflammation, manage scleritis, and prevent and treat cystoid macular edema associated with cataract surgery. In addition, they may decrease postoperative pain and photophobia associated with refractive surgery and may reduce the itching associated with allergic conjunctivitis. In recent years, the U.S. Food and Drug Administration has approved new topical NSAIDs, and previously approved NSAIDs have been reformulated. These additions and changes result in different pharmacokinetics and dosing intervals, which may offer therapeutic advantages. For example, therapeutic effects on diabetic retinopathy and age-related macular degeneration may now be achievable. We provide an updated review on NSAIDs and a summary of their current uses in ophthalmology with attention to potential future applications.
ISSN:0039-6257
1879-3304
DOI:10.1016/j.survophthal.2009.07.005