Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection

Oral Diseases (2010) 16, 156–159 Objectives:  The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non‐neoplastic jaw cysts – periapical cysts, as well as to establish a possible relationship b...

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Published in:Oral diseases 2010-03, Vol.16 (2), p.156-159
Main Authors: Andric, M, Dozic, B, Popovic, B, Stefanovic, D, Basta-Jovanovic, G, Djogo, N, Andjus, P, Milasin, J
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Apoptosis Regulatory Proteins - analysis
Connective Tissue - pathology
cytomegalovirus
Cytomegalovirus Infections - pathology
Cytoplasm - ultrastructure
Cytoplasm - virology
Dentistry
Epithelial Cells - pathology
Epithelium - pathology
Humans
Immunohistochemistry
Inhibitor of Apoptosis Proteins
keratocystic odontogenic tumor
Microscopy, Confocal
Microtubule-Associated Proteins - analysis
Odontogenic Cysts - pathology
Odontogenic Cysts - virology
odontogenic keratocyst
periapical cyst
Radicular Cyst - pathology
Radicular Cyst - virology
survivin expression
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Summary:Oral Diseases (2010) 16, 156–159 Objectives:  The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non‐neoplastic jaw cysts – periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus presence within these cysts. Materials and methods:  Samples of 10 odontogenic keratocysts (five positive and five negative for the presence of cytomegalovirus, as determined by polymerase chain reaction) and 10 periapical cysts (five positive and five negative for the cytomegalovirus presence) were analysed. The expression of survivin was assessed by immunohistochemical methods, using monoclonal antibody that selectively recognizes the cytoplasmic form of survivin. Results:  All 10 odontogenic keratocysts showed immunostaining for survivin, while all 10 periapical cysts were negative for its presence. There was no correlation between cytomegalovirus presence and expression of survivin within odontogenic keratocysts. Conclusion:  Survivin may contribute to the aggressive behavior of odontogenic keratocysts, and thus support the emerging opinion of their neoplastic nature.
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2009.01612.x