Polygenic model for predicting breast cancer risk via genome-wide polymorphisms

A polygenic model for predicting susceptibility to late-onset, sporadic forms of breast-cancer based on an individual's SNP profile was developed. The model was validated using a publicly available data set with genome-wide SNP markers for cases and controls. Preliminary results show that this...

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Bibliographic Details
Published in:AMIA ... Annual Symposium proceedings 2008-11, p.1094-1094
Main Authors: Piccolo, Stephen R, Camp, Nicola, Frey, Lewis J
Format: Article
Language:English
Subjects:
Breast Neoplasms - diagnosis
Breast Neoplasms - epidemiology
Breast Neoplasms - genetics
Chromosome Mapping - methods
Computer Simulation
Diagnosis, Computer-Assisted - methods
Female
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Genetic Testing - methods
Humans
Models, Genetic
Polymorphism, Single Nucleotide - genetics
Proportional Hazards Models
Risk Assessment - methods
Risk Factors
Utah
Online Access:Get full text
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Summary:A polygenic model for predicting susceptibility to late-onset, sporadic forms of breast-cancer based on an individual's SNP profile was developed. The model was validated using a publicly available data set with genome-wide SNP markers for cases and controls. Preliminary results show that this method performs better than expected by chance.
ISSN:1559-4076