Studies on the synthesis andin vitro anti-tumor activity of dihydroberberine derivatives

Three types of dihydroberberine derivatives such as spirobenzylisoquinoline, benzindenoazepine and cyclopropanated quinolizine species were synthesized from dihydroberberine for the investigation on their anti-tumor activity. Among them, cyclopropanated quinolizine species were more effective than s...

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Bibliographic Details
Published in:Archives of pharmacal research 1997-10, Vol.20 (5), p.476-479
Main Authors: Kim, I J, Park, Y J, Kim, J I, Lee, K T, Kim, S K
Format: Article
Language:English
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Summary:Three types of dihydroberberine derivatives such as spirobenzylisoquinoline, benzindenoazepine and cyclopropanated quinolizine species were synthesized from dihydroberberine for the investigation on their anti-tumor activity. Among them, cyclopropanated quinolizine species were more effective than spirobenzylisoquinoline and benzindenoazepine against P-388 and L-1210 leukemia cell.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02973943