Fetomaternal immunotolerance

Implantation of mammalian conceptus in uterine cavity is the result of evolutionary adaptation, through high level of physiological procedures to ensure its success. However the majority of pregnancy losses occur before or during implantation. It is expected that exploring and defining the molecular...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2008-12, Vol.60 (6), p.482-496
Main Authors: Makrigiannakis, Antonis, Karamouti, Maria, Drakakis, Petros, Loutradis, Dimitris, Antsaklis, Aris
Format: Article
Language:English
Subjects:
Animals
Decidua - chemistry
Decidua - immunology
Decidua - metabolism
Embryo Implantation - immunology
Female
Fetus - chemistry
Fetus - immunology
Fetus - metabolism
Humans
Immune Tolerance - immunology
Maternal-Fetal Exchange - immunology
Pregnancy
Trophoblasts - chemistry
Trophoblasts - immunology
Trophoblasts - metabolism
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Summary:Implantation of mammalian conceptus in uterine cavity is the result of evolutionary adaptation, through high level of physiological procedures to ensure its success. However the majority of pregnancy losses occur before or during implantation. It is expected that exploring and defining the molecular and physiological road map during the crucial time of implantation will enable us to decode and effectively treat fertility defects. Immunological, hormonal and molecular factors participate in the feto-maternal cross talk during implantation and designate the effectiveness of the process. The atypical expression of major histocompatibility complex and other protein-antigens, such as Fas/FasL and petformin in human trophoblast, the modified function of cellular constituents of the feto-maternal interface, as well as the specific role of some hormones and cytokines, represent substantive parameters of feto-maternal immunotolerance during implantation.
ISSN:1046-7408
1600-0897
DOI:10.1111/j.1600-0897.2008.00655.x