The beneficial role of vitamin D and its analogs in cancer treatment and prevention

Abstract Background Cancer is the leading cause of death in the United States, and the probability of developing cancer increases dramatically with age. Interestingly, vitamin D deficiency is also recognized more often in people of advanced ages. A potential relationship between vitamin D deficiency...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2010-03, Vol.73 (3), p.192-201
Main Authors: Luong, Khanh vinh quoc, Nguyen, Lan Thi Hoang
Format: Article
Language:English
Subjects:
1,25-Dihydroxyvitamin D 3
Animals
Biological and medical sciences
Calcitriol
Cancer
Genetic Predisposition to Disease
Hematologic and hematopoietic diseases
Hematology, Oncology and Palliative Medicine
Humans
Medical sciences
Neoplasms - drug therapy
Neoplasms - etiology
Neoplasms - genetics
Neoplasms - prevention & control
Tumor
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - therapeutic use
Vitamin D Deficiency - etiology
Vitamin D Deficiency - genetics
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Summary:Abstract Background Cancer is the leading cause of death in the United States, and the probability of developing cancer increases dramatically with age. Interestingly, vitamin D deficiency is also recognized more often in people of advanced ages. A potential relationship between vitamin D deficiency and cancer has been reported in the literature. Method Review Medline database literature and discuss the relationship between vitamin D status and cancer. Results Environmental (including seasonal and geographic) and genetic factors contribute to the development of both vitamin D deficiency and cancer. The vitamin D receptor is present in many tissues, especially in malignant cells, and may contribute to the successful use of vitamin D and its analogs in the treatment of some cancer patients. Conclusion Further investigation of the role of vitamin D in the treatment of cancer is warranted.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2009.04.008