Stimulation of protective and cross-protective immunity against influenza B virus after adjuvant mucosal immunization of mice

Intratracheal immunization of mice with inactivated influenza B virus and delipidated Bacillus firmus as adjuvant increases protection of mice against infection with the homologous virus strain and induces cross-protection: mice immunized by influenza virus B/Yamanashi 166/98 were protected even aga...

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Bibliographic Details
Published in:Folia microbiologica 2009-11, Vol.54 (6), p.549-552
Main Authors: Prokešová, L., Zanvit, P., Havlíčková, M., Táčner, J., Jirkovská, M., Petrásková, P., Novotná, O., Čechová, D., Julák, J.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Administration, Inhalation
Animals
Applied Microbiology
Bacillus - immunology
Biomedical and Life Sciences
Cross Protection
Environmental Engineering/Biotechnology
Female
Immune system
Immunization
Immunization - methods
Immunology
Influenza B virus - immunology
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Life Sciences
Mice
Mice, Inbred BALB C
Microbiology
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - prevention & control
Rodents
Survival Analysis
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - immunology
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Summary:Intratracheal immunization of mice with inactivated influenza B virus and delipidated Bacillus firmus as adjuvant increases protection of mice against infection with the homologous virus strain and induces cross-protection: mice immunized by influenza virus B/Yamanashi 166/98 were protected even against phylogenetically distant virus drift variant B/Lee/40 lethal for mice.
ISSN:0015-5632
1874-9356
DOI:10.1007/s12223-009-0080-z