Reperfusion arrhythmias after chronic regional denervation of the ischaemic myocardium in pigs

• Published in: Cardiovascular research 1992-10, Vol.26 (10), p.962-967
• Main Authors: Cinca, Juan, Worner, Fernando, Carreño, Ana, Bardají, Alfredo, Salas-Caudevilla, Antonio, Soler-Soler, J
• Format: Article
• Language: English
• Subjects: adrenergic histofluorescence; Animals; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - metabolism; Arrhythmias, Cardiac - prevention & control; Biological and medical sciences; Cardiology. Vascular system; Catecholamines - analysis; Coronary heart disease; coronary reperfusion; Disease Models, Animal; Electrocardiography; epicardial electrograms; Fluorescent Antibody Technique; Heart; Medical sciences; myocardial ischaemia; Myocardial Ischemia - complications; Myocardial Ischemia - metabolism; Myocardial Reperfusion Injury - complications; Myocardial Reperfusion Injury - metabolism; Myocardium - chemistry; refractory period; Swine; Sympathectomy; sympathetic denervation
• ISSN: 0008-6363; 1755-3245
• DOI: 10.1093/cvr/26.10.962

Objective: The aim was to assess the effects of chronic regional denervation of the ischaemic myocardium on reperfusion arrhythmias in a model with sparse coronary collateral circulation. Methods: Baseline ventricular refractoriness and epicardial activation times were measured together with reperfusion arrhythmias after 15 min (I-15′) or 30 min (I-30′) of left anterior descending coronary artery occlusion in 38 barbiturate anaesthetised open chest pigs. Twenty pigs (11 in I-15′ and nine in I-30′) had a chronic (two week) denervation of the left anteroseptal region, whereas 18 pigs (10 in I-15′ and eight in I-30′) were sham operated (non-denervated) controls. Denervation was induced by pericoronary application of phenol and verified by absence of adrenergic histofluorescence. Results: As compared with controls, denervated pigs showed: (1) longer activation times: 20.3(SD 5.2) ms v 16.5(4.6) ms, p