Increment of interleukin 6, tumour necrosis factor alpha, nitric oxide, C-reactive protein and apoptosis in dengue

This study evaluated the levels of TNFα, IL-6, IL-1β, nitric oxide (NO), CRP, C3 and apoptosis in 36 patients with dengue fever (DF), 34 patients with dengue haemorrhagic fever (DHF) and in virus-infected monocyte cultures. IL-6, TNFα, NO (nitrites) and CRP levels were increased and C3 diminished in...

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Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2010, Vol.104 (1), p.16-23
Main Authors: Levy, Alegria, Valero, Nereida, Espina, Luz Marina, Añez, Germán, Arias, Julia, Mosquera, Jesús
Format: Article
Language:English
Subjects:
Adolescent
Adult
Apoptosis
Biomarkers - metabolism
C-Reactive Protein - metabolism
Child
Child, Preschool
Complement
Cytokines
Dengue
Dengue - immunology
Dengue - virology
Dengue Virus - immunology
Dengue virus type 4
Female
Gene Expression Regulation, Enzymologic
Humans
Interleukin-6 - metabolism
Male
Middle Aged
Monocytes
Nitric Oxide - metabolism
Tumor Necrosis Factor-alpha - metabolism
Venezuela
Young Adult
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Summary:This study evaluated the levels of TNFα, IL-6, IL-1β, nitric oxide (NO), CRP, C3 and apoptosis in 36 patients with dengue fever (DF), 34 patients with dengue haemorrhagic fever (DHF) and in virus-infected monocyte cultures. IL-6, TNFα, NO (nitrites) and CRP levels were increased and C3 diminished in patients with DF and DHF. IL-6, TNFα, CPR and C3 values were associated with disease severity (DHF). Nitrite content was incremented in DF patients. TNFα, NO and CRP levels were associated with secondary infection. IL-6 and CRP levels were associated with dengue virus type 4 (DENV-4) and DENV-2, respectively. Low levels of C3 were associated with DENV-2 and DENV-4 infections. Similarly, increased content of TNFα, IL-6 and nitrites were observed in supernatants from infected monocyte cultures. IL-6 was associated with DENV-4 infection. The different virus serotypes induced apoptosis in monocyte cultures. Dengue infection did not induce elevated IL-1β production, either in patients or in infected cultures. These results suggest that TNFα, IL-6, NO and CRP are involved in dengue infection and that monocytes could be an important source of cytokine and NO production.
ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2009.06.013