STAT3 polymorphisms linked with idiopathic recurrent miscarriages

We investigated the association of signal transducers and activators of transcription (STAT)3 gene variants with idiopathic recurrent miscarriage (RM). A case-control study involving 189 RM patients and 244 control women was carried out. STAT3 (rs1053004 and rs1023023) genotyping was performed by al...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2010-01, Vol.63 (1), p.22-27
Main Authors: Finan, Ramzi R, Mustafa, Fekriya E, Al-Zaman, Intissar, Madan, Samira, Issa, Abdalla A, Almawi, Wassim Y
Format: Article
Language:English
Subjects:
Abortion, Habitual - genetics
Adult
Female
Genetic Predisposition to Disease
Genetic Variation
Humans
Polymorphism, Genetic
Pregnancy
STAT3 Transcription Factor - genetics
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Summary:We investigated the association of signal transducers and activators of transcription (STAT)3 gene variants with idiopathic recurrent miscarriage (RM). A case-control study involving 189 RM patients and 244 control women was carried out. STAT3 (rs1053004 and rs1023023) genotyping was performed by allelic discrimination/real-time PCR method. STAT3 rs1053004 C allele [OR (95% CI) = 1.60 (1.22-2.10)] and C/C genotype [OR (95% CI) = 3.42 (1.70-6.92)] were positively associated with RM. Two-locus (rs1053004/rs1053023) haplotype analysis revealed increased frequency of CG and CA haplotypes in RM patients, of which only CA haplotype (Pc = 0.020) remained positively associated with RM after applying the Bonferroni correction. This was confirmed by multivariate regression analysis (OR = 1.70; 95% CI = 1.17-2.46) after adjusting for a number of covariates. STAT3 rs1053004 variant is significantly associated with idiopathic RM. Replication studies on other racial groups and other STAT3 gene variants are warranted.
ISSN:1046-7408
1600-0897
DOI:10.1111/j.1600-0897.2009.00765.x