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STAT3 polymorphisms linked with idiopathic recurrent miscarriages
We investigated the association of signal transducers and activators of transcription (STAT)3 gene variants with idiopathic recurrent miscarriage (RM). A case-control study involving 189 RM patients and 244 control women was carried out. STAT3 (rs1053004 and rs1023023) genotyping was performed by al...
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| Published in: | American journal of reproductive immunology (1989) 2010-01, Vol.63 (1), p.22-27 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 27 |
| container_issue | 1 |
| container_start_page | 22 |
| container_title | American journal of reproductive immunology (1989) |
| container_volume | 63 |
| creator | Finan, Ramzi R Mustafa, Fekriya E Al-Zaman, Intissar Madan, Samira Issa, Abdalla A Almawi, Wassim Y |
| description | We investigated the association of signal transducers and activators of transcription (STAT)3 gene variants with idiopathic recurrent miscarriage (RM).
A case-control study involving 189 RM patients and 244 control women was carried out. STAT3 (rs1053004 and rs1023023) genotyping was performed by allelic discrimination/real-time PCR method.
STAT3 rs1053004 C allele [OR (95% CI) = 1.60 (1.22-2.10)] and C/C genotype [OR (95% CI) = 3.42 (1.70-6.92)] were positively associated with RM. Two-locus (rs1053004/rs1053023) haplotype analysis revealed increased frequency of CG and CA haplotypes in RM patients, of which only CA haplotype (Pc = 0.020) remained positively associated with RM after applying the Bonferroni correction. This was confirmed by multivariate regression analysis (OR = 1.70; 95% CI = 1.17-2.46) after adjusting for a number of covariates.
STAT3 rs1053004 variant is significantly associated with idiopathic RM. Replication studies on other racial groups and other STAT3 gene variants are warranted. |
| doi_str_mv | 10.1111/j.1600-0897.2009.00765.x |
| format | article |
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A case-control study involving 189 RM patients and 244 control women was carried out. STAT3 (rs1053004 and rs1023023) genotyping was performed by allelic discrimination/real-time PCR method.
STAT3 rs1053004 C allele [OR (95% CI) = 1.60 (1.22-2.10)] and C/C genotype [OR (95% CI) = 3.42 (1.70-6.92)] were positively associated with RM. Two-locus (rs1053004/rs1053023) haplotype analysis revealed increased frequency of CG and CA haplotypes in RM patients, of which only CA haplotype (Pc = 0.020) remained positively associated with RM after applying the Bonferroni correction. This was confirmed by multivariate regression analysis (OR = 1.70; 95% CI = 1.17-2.46) after adjusting for a number of covariates.
STAT3 rs1053004 variant is significantly associated with idiopathic RM. Replication studies on other racial groups and other STAT3 gene variants are warranted.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/j.1600-0897.2009.00765.x</identifier><identifier>PMID: 20059466</identifier><language>eng</language><publisher>Denmark</publisher><subject>Abortion, Habitual - genetics ; Adult ; Female ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Polymorphism, Genetic ; Pregnancy ; STAT3 Transcription Factor - genetics</subject><ispartof>American journal of reproductive immunology (1989), 2010-01, Vol.63 (1), p.22-27</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20059466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Finan, Ramzi R</creatorcontrib><creatorcontrib>Mustafa, Fekriya E</creatorcontrib><creatorcontrib>Al-Zaman, Intissar</creatorcontrib><creatorcontrib>Madan, Samira</creatorcontrib><creatorcontrib>Issa, Abdalla A</creatorcontrib><creatorcontrib>Almawi, Wassim Y</creatorcontrib><title>STAT3 polymorphisms linked with idiopathic recurrent miscarriages</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>We investigated the association of signal transducers and activators of transcription (STAT)3 gene variants with idiopathic recurrent miscarriage (RM).
A case-control study involving 189 RM patients and 244 control women was carried out. STAT3 (rs1053004 and rs1023023) genotyping was performed by allelic discrimination/real-time PCR method.
STAT3 rs1053004 C allele [OR (95% CI) = 1.60 (1.22-2.10)] and C/C genotype [OR (95% CI) = 3.42 (1.70-6.92)] were positively associated with RM. Two-locus (rs1053004/rs1053023) haplotype analysis revealed increased frequency of CG and CA haplotypes in RM patients, of which only CA haplotype (Pc = 0.020) remained positively associated with RM after applying the Bonferroni correction. This was confirmed by multivariate regression analysis (OR = 1.70; 95% CI = 1.17-2.46) after adjusting for a number of covariates.
STAT3 rs1053004 variant is significantly associated with idiopathic RM. Replication studies on other racial groups and other STAT3 gene variants are warranted.</description><subject>Abortion, Habitual - genetics</subject><subject>Adult</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Variation</subject><subject>Humans</subject><subject>Polymorphism, Genetic</subject><subject>Pregnancy</subject><subject>STAT3 Transcription Factor - genetics</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwC8grWCWMH7WdZVXxkiqxIKyj1JlQl6QJdiLo32NEYcndzOjOmdHoEkIZpCzqZpsyBZCAyXTKAbIUQKt5-nlEpn-D49iDVImWYCbkLIQtQPSFPiWTuDPPpFJTsnjOF7mgfdfs2873GxfaQBu3e8OKfrhhQ13lur4cNs5Sj3b0HncDbV2wpfeufMVwTk7qsgl4cagz8nJ3my8fktXT_eNysUp6LtmQIFdopWWVZNzWUkpltVgbi1pXKAwKraGs14xHUFWMATALhtW14XPUgGJGrn_u9r57HzEMxfcX2DTlDrsxFFoIY0yWiUhe_UtyxpWQnEfw8gCO6xaroveuLf2--I1HfAHwYGij</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Finan, Ramzi R</creator><creator>Mustafa, Fekriya E</creator><creator>Al-Zaman, Intissar</creator><creator>Madan, Samira</creator><creator>Issa, Abdalla A</creator><creator>Almawi, Wassim Y</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201001</creationdate><title>STAT3 polymorphisms linked with idiopathic recurrent miscarriages</title><author>Finan, Ramzi R ; Mustafa, Fekriya E ; Al-Zaman, Intissar ; Madan, Samira ; Issa, Abdalla A ; Almawi, Wassim Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p241t-e26ec4c1d412cf4446c73b8ce77de38e3770afb12e266d11001c081ff825e70e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abortion, Habitual - genetics</topic><topic>Adult</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Variation</topic><topic>Humans</topic><topic>Polymorphism, Genetic</topic><topic>Pregnancy</topic><topic>STAT3 Transcription Factor - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Finan, Ramzi R</creatorcontrib><creatorcontrib>Mustafa, Fekriya E</creatorcontrib><creatorcontrib>Al-Zaman, Intissar</creatorcontrib><creatorcontrib>Madan, Samira</creatorcontrib><creatorcontrib>Issa, Abdalla A</creatorcontrib><creatorcontrib>Almawi, Wassim Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Finan, Ramzi R</au><au>Mustafa, Fekriya E</au><au>Al-Zaman, Intissar</au><au>Madan, Samira</au><au>Issa, Abdalla A</au><au>Almawi, Wassim Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>STAT3 polymorphisms linked with idiopathic recurrent miscarriages</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2010-01</date><risdate>2010</risdate><volume>63</volume><issue>1</issue><spage>22</spage><epage>27</epage><pages>22-27</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>We investigated the association of signal transducers and activators of transcription (STAT)3 gene variants with idiopathic recurrent miscarriage (RM).
A case-control study involving 189 RM patients and 244 control women was carried out. STAT3 (rs1053004 and rs1023023) genotyping was performed by allelic discrimination/real-time PCR method.
STAT3 rs1053004 C allele [OR (95% CI) = 1.60 (1.22-2.10)] and C/C genotype [OR (95% CI) = 3.42 (1.70-6.92)] were positively associated with RM. Two-locus (rs1053004/rs1053023) haplotype analysis revealed increased frequency of CG and CA haplotypes in RM patients, of which only CA haplotype (Pc = 0.020) remained positively associated with RM after applying the Bonferroni correction. This was confirmed by multivariate regression analysis (OR = 1.70; 95% CI = 1.17-2.46) after adjusting for a number of covariates.
STAT3 rs1053004 variant is significantly associated with idiopathic RM. Replication studies on other racial groups and other STAT3 gene variants are warranted.</abstract><cop>Denmark</cop><pmid>20059466</pmid><doi>10.1111/j.1600-0897.2009.00765.x</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2010-01, Vol.63 (1), p.22-27 |
| issn | 1046-7408 1600-0897 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733888993 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Abortion, Habitual - genetics Adult Female Genetic Predisposition to Disease Genetic Variation Humans Polymorphism, Genetic Pregnancy STAT3 Transcription Factor - genetics |
| title | STAT3 polymorphisms linked with idiopathic recurrent miscarriages |
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