S100B serum levels are closely correlated with body mass index: An important caveat in neuropsychiatric research

Summary Elevated blood levels of S100B in neuropsychiatric disorders have so far been mainly attributed to glial pathologies. However, increases or dysfunction of adipose tissue may be alternatively responsible. Our study assessed S100B serum levels in 60 adult subjects without a prior history of ne...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2010-02, Vol.35 (2), p.321-324
Main Authors: Steiner, Johann, Schiltz, Kolja, Walter, Martin, Wunderlich, Michael T, Keilhoff, Gerburg, Brisch, Ralf, Bielau, Hendrik, Bernstein, Hans-Gert, Bogerts, Bernhard, Schroeter, Matthias L, Westphal, Sabine
Format: Article
Language:English
Subjects:
Adipose derived hormones
Adipose tissue
Adipose Tissue - metabolism
Adult
Behavioral psychophysiology
Biological and medical sciences
Body Mass Index
Body Size - physiology
Endocrinology & Metabolism
Fatty acid-binding protein
Fatty Acid-Binding Proteins - blood
Fatty Acid-Binding Proteins - metabolism
Female
Fundamental and applied biological sciences. Psychology
Hormones and behavior
Humans
Leptin
Leptin - blood
Leptin - metabolism
Male
Middle Aged
Nerve Growth Factors - blood
Nerve Growth Factors - metabolism
Neuropsychology - methods
Neuropsychology - standards
Obesity - blood
Obesity - metabolism
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Research Design
S-100B
S100 Calcium Binding Protein beta Subunit
S100 Proteins - blood
S100 Proteins - metabolism
S100B
Young Adult
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Summary:Summary Elevated blood levels of S100B in neuropsychiatric disorders have so far been mainly attributed to glial pathologies. However, increases or dysfunction of adipose tissue may be alternatively responsible. Our study assessed S100B serum levels in 60 adult subjects without a prior history of neuropsychiatric disorders. S100B concentrations were closely correlated with the body mass index (BMI, range 18–45 kg/m2 ) as well as levels of leptin and adipocyte-type fatty acid-binding protein (A-FABP/FABP4) that are well-known adipose-related factors. Effect sizes as measured by Cohen's d indicated medium (0.8 > d > 0.5) to strong effects ( d > 0.9) of BMI on S100B blood levels. In conclusion, physiological S100B levels in humans appear to closely reflect adipose tissue mass, which should therefore be considered as an important confounding factor in clinical studies examining the role of S100B.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2009.07.012