Predictors of health‐related quality of life in patients with chronic liver disease

• Published in: Alimentary pharmacology & therapeutics 2009-09, Vol.30 (5), p.469-476
• Main Authors: AFENDY, A., KALLMAN, J. B., STEPANOVA, M., YOUNOSZAI, Z., AQUINO, R. D., BIANCHI, G., MARCHESINI, G., YOUNOSSI, Z. M.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Chronic Disease; Digestive system; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver Diseases - physiopathology; Liver Diseases - psychology; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Psychometrics; Quality of Life; Severity of Illness Index; Young Adult
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/j.1365-2036.2009.04061.x

Summary Background  Patient‐reported outcomes like health‐related quality of life (HRQL) have become increasingly important for full assessment of patients with chronic liver diseases (CLD). Aim  To explore the relative impact of different types of liver disease on HRQL as well as predictors of HRQL domains in CLD. Methods  Our HRQL databases with Short‐Form 36 (SF‐36) data were used. Scores for each of SF‐36 scales (PF – physical functioning, RP – role functioning, BP – bodily pain, GH – general health, VT – vitality, SF – social functioning, RE – role emotional and MH – mental health, MCS – mental component score, PCS – physical component score) were compared between different types of CLD as well as other variables. Results  Complete data were available for 1103 CLD patients. Demographic and clinical data included: age 54.2 ± 12.0 years, 40% female, 761 (69%) with cirrhosis. Analysis revealed that age correlated significantly (P