Immune Memory: the Basics and How to Trigger an Efficient Long-Term Immune Memory

Immunological memory consists of expanded clones of T and B lymphocytes that show an increased rate of cell division and shortened telomeres compared with naïve cells. However, exhaustion of clones is delayed by kinetic heterogeneity within clones and altered survival and up-regulation of telomerase...

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Bibliographic Details
Published in:Journal of comparative pathology 2010, Vol.142, p.S91-S95
Main Author: Beverley, P.C.L.
Format: Article
Language:English
Subjects:
B-Lymphocytes - immunology
Humans
Immunologic Memory - immunology
kinetics
Lymphocyte Activation - immunology
memory
protection
T-Lymphocytes - immunology
Telomerase - immunology
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Summary:Immunological memory consists of expanded clones of T and B lymphocytes that show an increased rate of cell division and shortened telomeres compared with naïve cells. However, exhaustion of clones is delayed by kinetic heterogeneity within clones and altered survival and up-regulation of telomerase. Prolonged maintenance of protective B-cell immunity is T-cell dependent and requires a balance between plasma cells and memory B cells. Protective T-cell immunity also requires correct quality of T cells and that they are located appropriately.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2009.09.008