Preparation of Thai silk fibroin/gelatin electrospun fiber mats for controlled release applications

This work studied the effect of preparation conditions for electrospun fiber mats of Thai silk fibroin/type B gelatin (SF/GB) for controlled release applications. The increasing in applied voltage resulted in decreased average fiber size and narrow fiber size distribution. An increasing in silk fibr...

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Bibliographic Details
Published in:International journal of biological macromolecules 2010-06, Vol.46 (5), p.544-550
Main Authors: Okhawilai, Manunya, Rangkupan, Ratthapol, Kanokpanont, Sorada, Damrongsakkul, Siriporn
Format: Article
Language:English
Subjects:
Animals
Controlled release
Cross-Linking Reagents - chemistry
Delayed-Action Preparations - chemical synthesis
Delayed-Action Preparations - chemistry
Electricity
Electrochemistry - methods
Electrospinning
Fibroins - chemical synthesis
Fibroins - ultrastructure
Gelatin
Gelatin - chemical synthesis
Methylene Blue - chemistry
Silk fibroin
Solutions
Thailand
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Summary:This work studied the effect of preparation conditions for electrospun fiber mats of Thai silk fibroin/type B gelatin (SF/GB) for controlled release applications. The increasing in applied voltage resulted in decreased average fiber size and narrow fiber size distribution. An increasing in silk fibroin content in blended solution resulted in larger size of the obtained electrospun fibers. Smooth fibers could be produced from SF/GB blended solution at weight blending ratios of 10/90, 20/80, 30/70, 40/60 and 50/50. The results on in vitro biodegradation test showed that SF/GB 10/90 electrospun fiber mat was rapidly degraded in collagenase solution due to direct biodegradation of gelatin by collagenase. From in vitro controlled release of two active agents (azo-casein and methylene blue) from SF/GB blended fiber mats, it was suggested that methylene blue could be adsorbed on the blended fiber mats, possibly due to attractive interaction of the positively charged molecules of methylene blue and negatively charged SF/GB fiber mats. In contrast, the same charge of blended fiber mats and azo-casein would result in the repulsive force, resulting in continuous diffusion of azo-casein from blended fiber mats within 72 h. The results indicated that SF/GB electrospun fiber mats had a high potential to be applied in controlled release applications.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2010.02.008