Dietary n-3 fatty acids reduce antibody-dependent cell cytotoxicity and alter eicosanoid release by chicken immune cells

The overall goal of the present study was to determine whether the incorporation of n-3 fatty acids into poultry rations would alter the immune response of broiler chickens. Female broiler chicks were fed a corn and soybean meal-based diet to which one of four dietary fats were added:lard (LA), corn...

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Bibliographic Details
Published in:Poultry science 1992-10, Vol.71 (10), p.1646-1657
Main Authors: Fritsche, K.L. (University of Missouri-Columbia, Columbia, MO), Cassity, N.A
Format: Article
Language:English
Subjects:
ACIDE GRAS INSATURE
ACIDOS GRASOS INSATURADOS
Animals
Antibody Formation
Antibody-Dependent Cell Cytotoxicity - drug effects
BAZO
BOLSA DE FABRICIO
BOURSE DE FABRICIUS
Calcimycin - pharmacology
CELLULE
CELULAS
Chickens - immunology
CORPS GRAS
DIETA
Dietary Fats - pharmacology
DOSAGE BIOLOGIQUE
EFFICACITE
EFFICACITE ALIMENTAIRE
EFICACIA
EFICIENCIA DE CONVERSION DEL PIENSO
Eicosanoids - metabolism
ENSAYO BIOLOGICO
Fatty Acids - metabolism
Fatty Acids, Omega-3 - pharmacology
Female
Fish Oils - pharmacology
GRASAS
Leukocytes - immunology
Leukocytes - metabolism
Leukotriene B4 - metabolism
LIPIDE
LIPIDOS
PESO
POIDS
POLLO DE ENGORDE
POULET DE CHAIR
RATE
REGIME ALIMENTAIRE
REPONSE IMMUNITAIRE
RESPUESTA INMUNOLOGICA
Spleen - cytology
Spleen - immunology
Thromboxane B2 - metabolism
THYMUS (GENERO)
THYMUS (GENRE)
TOXICIDAD
TOXICITE
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Summary:The overall goal of the present study was to determine whether the incorporation of n-3 fatty acids into poultry rations would alter the immune response of broiler chickens. Female broiler chicks were fed a corn and soybean meal-based diet to which one of four dietary fats were added:lard (LA), corn oil (CO), flaxseed oil (SO), or menhaden fish oil (FO). The latter two fat sources are rich in n-3 polyunsaturated fatty acids (PUFA). Enriching the diet with n-3 PUFA did not alter the primary or secondary antibody response of broiler chickens to sheep red blood cells. Dietary fat source had no effect on antibody-dependent cell cytotoxicity (ADCC) by peripheral blood leukocytes, but ADCC by splenocytes was 50% lower in chickens fed SO and FO compared with LA and CO (P 0.005). As expected, the fatty acid profile of the isolated immune cells reflected the fatty acid composition of the dietary fats fed. Basal release and calcium ionophore (A23187)-stimulated (10 micromole release of thromboxane B were significantly lower (P 0.05) in the SO and FO groups compared with the LA and CO groups. Total leukotriene B release was not significantly altered by dietary fat source. In conclusion, feeding broiler chickens diets rich in n-3 PUFA reduced ADCC of splenocytes arid altered eicosanoid production by isolated immune cells
ISSN:0032-5791
1525-3171
DOI:10.3382/ps.0711646