A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition

The aim of the current study was to investigate the oral antidiabetic activity of six structurally related flavonoids: flavone (1), 3-hydroxyflavone (2), 6-hydroxyflavone (3), 7-hydroxyflavone (4), chrysin (5) and quercetin (6). Normoglycemic and STZ-nicotinamide diabetic rats were treated with thes...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2010-06, Vol.45 (6), p.2606-2612
Main Authors: Torres-Piedra, Mariana, Ortiz-Andrade, Rolffy, Villalobos-Molina, Rafael, Singh, Narender, Medina-Franco, Jose L, Webster, Scott P, Binnie, Margaret, Navarrete-Vázquez, Gabriel, Estrada-Soto, Samuel
Format: Article
Language:English
Subjects:
11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors
11-beta-Hydroxysteroid Dehydrogenase Type 1 - chemistry
11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism
Animals
Blood Glucose - metabolism
Computational Biology
Databases, Factual
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - enzymology
Diabetes Mellitus, Experimental - metabolism
Humans
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - metabolism
Hypoglycemic Agents - pharmacology
Lipids - blood
Models, Molecular
Molecular Conformation
Niacinamide - pharmacology
Quercetin - analogs & derivatives
Quercetin - chemistry
Quercetin - metabolism
Quercetin - pharmacology
Rats
Software
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Summary:The aim of the current study was to investigate the oral antidiabetic activity of six structurally related flavonoids: flavone (1), 3-hydroxyflavone (2), 6-hydroxyflavone (3), 7-hydroxyflavone (4), chrysin (5) and quercetin (6). Normoglycemic and STZ-nicotinamide diabetic rats were treated with these flavonoids (50 mg/kg) and the hypoglycemic and antidiabetic effects in acute and sub acute (five days of treatment) experiments were determined. Compounds 1, 5 and 6 were found most active in both experiments in comparison with control group (p
ISSN:1768-3254
DOI:10.1016/j.ejmech.2010.02.049