Chemokines in the vascular inflammatory response of atherosclerosis

Atherosclerosis is considered to be a chronic inflammatory disease of the vessel wall that encompasses the accumulation of lipids, and it is critically shaped by the recruitment of leucocytes during all phases of the disease. In addition, the progression of atherosclerosis is determined by a disturb...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular research 2010-05, Vol.86 (2), p.192-201
Main Authors: Zernecke, Alma, Weber, Christian
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis
Atherosclerosis - immunology
Blood Vessels - immunology
Cell Survival
Chemokines
Chemokines - immunology
Chemotaxis, Leukocyte
Humans
Inflammation
Inflammation - immunology
Inflammation Mediators - immunology
Leucocytes
Leukocytes - immunology
Receptors, Chemokine - immunology
Signal Transduction
T-Lymphocytes - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Atherosclerosis is considered to be a chronic inflammatory disease of the vessel wall that encompasses the accumulation of lipids, and it is critically shaped by the recruitment of leucocytes during all phases of the disease. In addition, the progression of atherosclerosis is determined by a disturbed equilibrium of immune responses. Chemokines and their receptors are instrumental in orchestrating the influx of leucocytes to the vascular wall, but also seem to regulate immune functions. Recent work has shed light on the apparent redundancy and the robustness of the chemokine system and has also provided evidence for its specialized role in the regulation of specific functions and trafficking of leucocyte subpopulations. This review will give a comprehensive summary to highlight those chemokines addressed in different models of atherosclerosis and vascular injury to date. In addition, we will discuss recent developments scrutinizing heterophilic interactions of chemokines that have advanced our understanding of how chemokines control vascular inflammatory responses.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/cvp391