Analgesic Actions of Corticotropin-Releasing Factor (CRF) on Somatic Pain Sensitivity: Involvement of Glucocorticoid and CRF-2 Receptors

The aim of the present work was to study the involvement of glucocorticoid receptors and corticotropinreleasing factor type 2 receptors (CRF-2 receptors) in mediating the analgesic effects of CRF on somatic pain sensitivity. The involvement of glucocorticoid and CRF-2 receptors in the development of...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2009-11, Vol.39 (9), p.819-823
Main Authors: Yarushkina, N. I., Bagaeva, T. R., Filaretova, L. P.
Format: Article
Language:English
Subjects:
Analgesics
Analgesics - pharmacology
Animals
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Corticotropin-Releasing Hormone - pharmacology
Electric currents
Hormone Antagonists - pharmacology
Hormones
Laboratory animals
Male
Mifepristone - pharmacology
Narcotics
Neurobiology
Neurosciences
Pain
Pain - drug therapy
Pain - metabolism
Physiology
Rats
Rats, Sprague-Dawley
Receptors, Corticotropin-Releasing Hormone - agonists
Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors
Receptors, Corticotropin-Releasing Hormone - metabolism
Receptors, Glucocorticoid - agonists
Receptors, Glucocorticoid - antagonists & inhibitors
Receptors, Glucocorticoid - metabolism
Solvents
Time Factors
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Summary:The aim of the present work was to study the involvement of glucocorticoid receptors and corticotropinreleasing factor type 2 receptors (CRF-2 receptors) in mediating the analgesic effects of CRF on somatic pain sensitivity. The involvement of glucocorticoid and CRF-2 receptors in the development of analgesia evoked by systemic administration of CRF was studied by blockade of these receptors by their specific antagonists RU 38486 and astressin 2-B, respectively, in anesthetized rats. Pain sensitivity was tested before and 30 min after administration of CRF in terms of the threshold of the pain reaction induced by stimulation of the rat’s tail with an electric current. Blockade of glucocorticoid receptors induced partial suppression of the analgesic action of CRF, while blockade of CRF-2 receptors produced complete suppression of the analgesic effect. These results provide evidence that glucocorticoid and CRF-2 receptors are involved in mediating the analgesic effects of CRF.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-009-9212-9