Delayed rectifier K+ currents and cardiac repolarization

Abstract The two components of the cardiac delayed rectifier current have been the subject of numerous studies since firstly described. This current controls the action potential duration and is highly regulated. After identification of the channel subunits underlying IKs, KCNQ1 associated with KCNE...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2010-01, Vol.48 (1), p.37-44
Main Authors: Charpentier, Flavien, Mérot, Jean, Loussouarn, Gildas, Baró, Isabelle
Format: Article
Language:English
Subjects:
Cardiovascular
ERG1 Potassium Channel
Ether-A-Go-Go Potassium Channels - genetics
Ether-A-Go-Go Potassium Channels - metabolism
Heart
Humans
K + currents
KCNQ1 Potassium Channel - genetics
KCNQ1 Potassium Channel - metabolism
Myocardium - metabolism
Myocardium - pathology
Potassium - metabolism
Potassium Channels, Voltage-Gated - genetics
Potassium Channels, Voltage-Gated - metabolism
Repolarization
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Summary:Abstract The two components of the cardiac delayed rectifier current have been the subject of numerous studies since firstly described. This current controls the action potential duration and is highly regulated. After identification of the channel subunits underlying IKs, KCNQ1 associated with KCNE1, and IKr, HERG, their involvement in human cardiac channelopathies have provided various models allowing the description of the molecular mechanisms of the KCNQ1 and HERG channels trafficking, activity and regulation. More recently, studies have been focusing on the unveiling of different partners of the pore-forming proteins that contribute to their maturation, trafficking, activity and/or degradation, on one side, and on their respective expression in the heterogeneous cardiac tissue, on the other side. The aim of this review is to report and discuss the major works on IKs and IKr and the most recent ones that help to understand the precise function of these currents in the heart.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2009.08.005