Plasma cortisol response to ACTH challenge in hypoxic newborn piglets resuscitated with 21% and 100% oxygen

Although the use of supplemental oxygen to resuscitate asphyxiated neonates remains controversial, the effects of hypoxia and reoxygenation (room air versus pure oxygen) on the hypothalamo-pituitary-adrenal axis are unknown. We aimed to evaluate the effect of hypoxia and reoxygenation with either 21...

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Bibliographic Details
Published in:Shock (Augusta, Ga.) Ga.), 2010-05, Vol.33 (5), p.519-525
Main Authors: Chapados, Isabelle, Chik, Constance L, Cheung, Po-Yin
Format: Article
Language:English
Subjects:
Adrenal Glands - metabolism
Adrenocorticotropic Hormone
Animals
Animals, Newborn
Cardiac Output
Hydrocortisone - blood
Hypoxia - blood
Hypoxia - physiopathology
Models, Animal
Oxygen - administration & dosage
Oxygen - therapeutic use
Receptor, Melanocortin, Type 2 - biosynthesis
Resuscitation - methods
Shock, Cardiogenic - blood
Shock, Cardiogenic - drug therapy
Steroidogenic Factor 1
Swine
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Summary:Although the use of supplemental oxygen to resuscitate asphyxiated neonates remains controversial, the effects of hypoxia and reoxygenation (room air versus pure oxygen) on the hypothalamo-pituitary-adrenal axis are unknown. We aimed to evaluate the effect of hypoxia and reoxygenation with either 21% or 100% oxygen on plasma cortisol before and after an adrenocorticotrophin (ACTH) challenge in newborn piglets. Thirty-five piglets (aged 1-3 days, weighing 1.5-2.4 kg) were instrumented to measure heart rate, MAP, and cardiac output. After 2 h of normocapnic hypoxia (PaO2, 20-30 mmHg; pH,
ISSN:1073-2322
1540-0514
DOI:10.1097/SHK.0b013e3181c99727