Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior

Objective: To screen for mutations in the coding region of the melanocortin-4 receptor (MC4R) gene and to assess the association between the rs17782313 variant near MC4R with childhood obesity and eating behavior. Subjects and methods: A cross-sectional sample of 221 obese Chilean children and 268 p...

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Bibliographic Details
Published in:Nutritional neuroscience 2010-04, Vol.13 (2), p.71-78
Main Authors: Valladares, M., Domínguez-Vásquez, P., Obregón, A.M., Weisstaub, G., Burrows, R., Maiz, A., Santos, J.L.
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Anthropometry
Appetite
Child
Child Behavior
Chile
Cross-Sectional Studies
DNA Mutational Analysis
EATING BEHAVIOR
Feeding Behavior
Female
Genetic Association Studies
Heterozygote
Humans
Male
MELANOCORTIN-4 RECEPTOR
Nerve Tissue Proteins - chemistry
Nerve Tissue Proteins - genetics
OBESITY
Obesity - blood
Obesity - genetics
Open Reading Frames - genetics
Parents
POLYMORPHISM
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Receptor, Melanocortin, Type 4 - chemistry
Receptor, Melanocortin, Type 4 - genetics
Satiety Response
Statistics as Topic
Surveys and Questionnaires
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Summary:Objective: To screen for mutations in the coding region of the melanocortin-4 receptor (MC4R) gene and to assess the association between the rs17782313 variant near MC4R with childhood obesity and eating behavior. Subjects and methods: A cross-sectional sample of 221 obese Chilean children and 268 parents were incorporated in the study to assemble 134 case-parent trios. We performed direct sequencing of the MC4R coding region while the rs17782313 variant was genotyped by a Taqman assay. Eating behavior scores were calculated using the Child Eating Behavior and Three Factor Eating Questionnaires adapted for Chilean families. Results: A low frequency of genetic variation in the coding region of MC4R was found in Chilean obese children (Thr150Ile mutation and polymorphisms Ile251Leu and Val103Ile). The rs17782313 variant is possibly associated with satiety responsiveness (P = 0.01) and enjoyment of food scores (P = 0.03). Conclusion: The rs17782313 variant may influence eating behavior in obese children.
ISSN:1028-415X
1476-8305
DOI:10.1179/147683010X12611460763643