Identification of polymorphisms in the RNase3 gene and the association with allergic rhinitis

Eosinophil cationic protein (ECP), a potent cytotoxic molecule, is released by activated eosinophils. ECP has been suggested to be involved in tissue remodeling of allergic diseases. The ECP ( RNase3 ) gene is a candidate gene in atopic diseases. RNase3 polymorphisms have been reported to have an as...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2010-03, Vol.267 (3), p.391-395
Main Authors: Kang, Inhong, An, Xue-hua, Oh, Yeon-Kyun, Lee, Sang Heon, Jung, Ha Min, Chae, Soo-Cheon, Lee, Jae Hoon
Format: Article
Language:English
Subjects:
Adult
Alleles
Biological and medical sciences
Eosinophil Cationic Protein - genetics
Female
Gene Frequency - genetics
Genetic Predisposition to Disease - genetics
Genetics, Population
Genotype
Haplotypes - genetics
Head and Neck Surgery
Humans
Male
Medical sciences
Medicine
Medicine & Public Health
Neurosurgery
Non tumoral diseases
Otorhinolaryngology
Otorhinolaryngology. Stomatology
Polymorphism, Genetic - genetics
Polymorphism, Restriction Fragment Length - genetics
Republic of Korea
Rhinitis, Allergic, Perennial - genetics
Rhinitis, Allergic, Seasonal - genetics
Rhinology
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Eosinophil cationic protein (ECP), a potent cytotoxic molecule, is released by activated eosinophils. ECP has been suggested to be involved in tissue remodeling of allergic diseases. The ECP ( RNase3 ) gene is a candidate gene in atopic diseases. RNase3 polymorphisms have been reported to have an association with atopy. We determined whether polymorphisms in the RNase3 gene are associated with allergic rhinitis in a Korean population. The Taqman assay, restriction fragment length polymorphism (PCR-RFLP), and high-resolution melt (HRM) were used for genotyping. Three single nucleotide polymorphisms (SNPs; g.−550A>G, g.371G>C, and g.499G>C) were identified. The genotype of the SNPs was analyzed in patients with allergic rhinitis and controls without allergic rhinitis. The genotype and allele frequencies were compared between both groups. The genotype frequencies of the g.−550A>G and g.371G>C SNPs were not significantly different between patients with allergic rhinitis and controls ( P  > 0.05). However, in patients with allergic rhinitis, the genotype and allele frequencies of the g.499G>C SNP of RNase 3 were significantly different from those of the control group ( P  
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-009-1103-8