Extramedullary hematopoiesis: A rare occurrence in the sinonasal tract

Abstract Extramedullary hematopoiesis (EMH) is a systemic reaction to inadequate hematopoiesis. We report two exceedingly rare cases of EMH involving the paranasal sinuses. The first patient, a 30-year-old man, presented with a maxillary sinus mass. The lesion was excised by endoscopic surgery: defi...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2010-04, Vol.37 (2), p.233-237
Main Authors: Bizzoni, Andrea, Lombardi, Davide, Maroldi, Roberto, Incardona, Paolo, Nicolai, Piero
Format: Article
Language:English
Subjects:
Adult
Chronic myeloproliferative disorder
Diagnosis, Differential
Endoscopy
Ethmoid Sinus - pathology
Ethmoid Sinus - physiopathology
Extramedullary hematopoiesis
Fibroma - diagnosis
Fibroma - pathology
Fibroma - physiopathology
Granuloma, Plasma Cell - diagnosis
Granuloma, Plasma Cell - pathology
Granuloma, Plasma Cell - physiopathology
Hematopoiesis, Extramedullary - physiology
Humans
Magnetic Resonance Imaging
Male
Maxillary Sinus - pathology
Maxillary Sinus - physiopathology
Maxillary Sinus Neoplasms - diagnosis
Maxillary Sinus Neoplasms - pathology
Maxillary Sinus Neoplasms - physiopathology
Nasal endoscopy
Otolaryngology
Paranasal Sinus Diseases - diagnosis
Paranasal Sinus Diseases - pathology
Paranasal Sinus Diseases - physiopathology
Sinonasal tract
Sphenoid Sinus - pathology
Sphenoid Sinus - physiopathology
Tomography, X-Ray Computed
β-Thalassemia
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Summary:Abstract Extramedullary hematopoiesis (EMH) is a systemic reaction to inadequate hematopoiesis. We report two exceedingly rare cases of EMH involving the paranasal sinuses. The first patient, a 30-year-old man, presented with a maxillary sinus mass. The lesion was excised by endoscopic surgery: definitive histology identified foci of EMH within an inflammatory fibromyxoid pseudotumor. The second case occurred in a 29-year-old man affected by intermediate β-thalassemia. He was hospitalized with a diagnosis of sphenoid sinus mucocele secondary to an ethmoid lesion. The patient underwent endoscopic excision of the mass and drainage of the sphenoid mucocele. At definitive histology, a diagnosis of EMH was established. Herein, the presenting modalities, imaging profile, and treatment options of this rare EMH localization are reviewed.
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2009.03.008